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Variant Onco Relevance

A variant is called onco-relevant if it is associated with oncological diseases. For such onco-relevant variants, clinical guidelines for the drug treatment of malignant tumors and maintenance therapy in oncology were developed by groups of experts studying cancer: Russian Society of Clinical Oncology (RUSSCO), Association of oncologists of Russia (Ассоциация онкологов России, АОР), the Ministry of Health of the Russian Federation (Министерство здравоохранения Российской Федерации, МЗ РФ), National Comprehensive Cancer Network (NCCN), European Society for Medical Oncology (ESMO).

In SNV Viewer, you can add "Onco Relevance" column (not included in the default columns) in column edit mode. If the variant is onco-relevant, then there will be the onco relevance button in this column. To open "Clinical Guidelines" tab of the variant details page, click on this button.

note

Variants can be filtered by "Onco Relevance" column using "Onco Relevance" filter in advanced filtering mode.

Clinical Guidelines#

The tab contains sections with clinical guidelines corresponding to a certain oncological disease (with which the variant is associated), its stage with details and therapy lines, which are indicated at the top of the section. Each section have subsections indicating the source of the guideline (RUSSCO, АОР, КР МЗ РФ, NCCN, ESMO) and containing the guideline itself. At the end of the section, the recommended drug is indicated (international nonproprietary name (международное непатентованное наименование, МНН)):

Specification of guidelines for the patient#

If you want to specify guidelines for the patient, please indicate his oncological disease, disease stage (I-IV) with details (relapse, progressing, inoperable, brain metastases) and therapy line (1-4 line, adjuvant or neoadjuvant therapy, perioperative, preoperative or induction chemotherapy). You can do this on the sample page or on "Sample" tab of the variant details page.

At Genomenal, clinical guidelines for variants associated with the following oncological diseases are available:

  • Non-small cell lung carcinoma;
  • Melanoma;
  • Neoplasm of the pancreas;
  • Breast carcinoma;
  • Ovarian neoplasm;
  • Prostate cancer;
  • Anaplastic thyroid carcinoma;
  • Colorectal carcinoma.

Guidelines corresponding to the selected disease, stage, stage details and therapy line are marked
with :

How to obtain a report with selected onco-relevant variants and clinical guidelines is described in the corresponding section.